ABSTRACT
Orf, also known as contagious pustular dermatitis, is anexanthemous disease caused by a parapox virus. It is usuallya benign locally self-limiting illness; it can have systemiccomplication or progressive infected locations can include thefinger, hand, arm, and face. Development of erythema multiforme following Orf infection is very rare. In Islamic populations suchas those of Iran, Orf can be observed in individuals who are notoccupationally involved, but may be in contact with sheep or goatsafter the Islamic worship as an "Eid ul-Adha." Here we reportan erythema multiforme associated with multiple lesion of Orfdisease following the "Eid ul-Adha" in Iranian housewives
ABSTRACT
Vitiligo is an acquired, idiopathic disorder characterized by circumscribed depigmented macules and patches. The exact etiology and pathogenesis of vitiligo is not clear. Many theories have been presented regarding this subject among them aautoimmune theory is the most important one. The association of vitiligo with other autoimmune disorders has been reported, but the relationship between vitiligo and celiac disease is controversial. The aim of this study was to study the frequency of celiac autoantibodies in a group of vitiligo patients compared with control. This was a cross sectional case control study that involved 128 individuals, 64 vitiligo patients and 64 individuals as control group. The means age of participants was 30.3 +/- 14.4 years. IgA anti Endomysial antibody and IgA anti-glutaminase antibody were measured by ELISA method in the serum of all participants. Data were analyzed by SPSS software version 15. The serum of two vitiligo patients [3.1%] was positive for antibodies. All control groups were seronegative for these antibodies [P < 0.05]. There was nosignificant effect of sex and job on seropositivity. There may be a relationship between celiac disease and vitiligo. This may indicate a common basic autoimmune mechanism that is an explanation for few case reports that gluten free diets were effective in the treatment of vitiligo patients. Both T test and exact fisher test showed no effect of age, sex and job anseropositivity of these patients [p=0.56 and p=0.74, respectively]